Back in mammals' earliest days, South America was just a small part of a single giant continent - Pangea. But Pangea broke apart, making South America an island.
Once South America went its own way, mammals were almost completely cut off from contact with the rest of the world for 60 million years. As they evolved, South America became populated with a mix of animals that existed nowhere else on Earth--like these giant sloths, and huge, slow-moving glyptodonts.